Product category:
Proteomics
News Release from: AnaSpec | Subject: Fluorinated amino acids
Edited by the Laboratorytalk Editorial
Team on 13 December 2006
Molecules with enhanced physiological
activities
The substitution of the fluorine in place of hydrogen in building blocks, such as amino acids, has produced molecules with enhanced physiological activities
The substitution of the fluorine in place of hydrogen in building blocks, such as amino acids, has produced molecules with enhanced physiological activities Some of these are antibacterial, antihypertensive and antitumoral
One reason for the enhanced activity is that fluorine forms a strong covalent bond with a carbon atom, which in peptides creates hyper-stable protein folds that render fluoro amino acid-containing peptides resistant to metabolic transformation.
The electronegativity of fluorine affects the pH of the neighboring groups, which in turn causes an overall change in the stability and reactivity of a molecule.
AnaSpec, a worldwide provider of integrated proteomics solutions, offers a wide collection of fluorinated amino acids.
• AnaSpec: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
