Study of pGlu modified beta-amyloid peptides

Edited by the Laboratorytalk editorial team Jan 24, 2007

In the October 17, 2006 issue of Biochemistry, researchers performed a study that characterised the oligomerisation and seeding capacity of pGlu-amyloid peptides

Their results identified pGlu-modified beta-amyloid peptides as displaying "up to 250-fold accelerated initial formation of aggregates compared to unmodified Abeta", adding further support to the idea that pGlu-amyloid peptides possess "biophysical characteristics that might be in particular crucial for the initiation of [Alzheimer's disease]." AnaSpec was one of the primary sources for the peptides used in this study.