Product category:
Antibodies
News Release from: AnaSpec | Subject: Anti-MMP antibodies
Edited by the Laboratorytalk Editorial
Team on 19 July 2007
AnaSpec introduces anti-MMP antibodies
Strategically raised against the hinge regions of MMP-1 and MMP-13, the epitopes do not overlap the catalytic domain and will not influence the activity of the MMP ferment in experiments.
AnaSpec has introduced its newest antibodies - anti-MMP-1 (Hinge) and anti-MMP-13 (Hinge) antibodies In response to customers' suggestions, AnaSpec's anti-MMP antibodies are packaged in efficient 50ul sizes
This article was originally published on Laboratorytalk on 7 Jun 2006 at 8.00am (UK)
Related stories
Reagents kits for study of protein phosphorylation
Cellular phosphorylation is a reversible covalent modification of a protein or lipid that modifies the activity of the phosphorylated molecule by inducing conformational changes within the molecule
In-house phosphoamino acids available to all
AnaSpec, a global producer of phosphopeptides, has made its own line of phosphoamino acids publicly available
Matrix metalloproteinases (MMPs) are a family of highly homologous protein-degrading zinc dependent enzymes endopeptidases.
These enzymes are responsible for the breakdown of connective tissues and are important in many normal biological processes including embryonic development, angiogenesis, bone remodelling, menstrual cycle, and wound healing.
They are also involved in pathological processes such as inflammation, cancer, multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, emphysema, glomerulonephritis, atherosclerosis, tissue ulceration, and tissue destruction.
Further reading
Custom phosphospecific antibody production service
The production of antibodies against phosphopeptides has often presented a challenge for researchers in search of high-quality results
The only HTS assay kits for screening HCV NS3/4A
EnzoLyte assay kits are specifically designed for the detection and quantification of NS3/4A protease activity at subnanomolar concentrations and can be used in 96- or 384-well microplate format
Imbalanced secretion of certain MMPs or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors.
This family currently includes more than 25 members that can be divided into collagenases (MMP-1, -8, -13 and -18), gelatinases (MMP-2 and -9), stromelysins (MMP-3 - 7, -10, -11and -13), matrilysins (MMP-7 and -26), elastins (MMP-12), and the membrane-type MMPs (MMP-14 to - 17, -20, and -21), according to their structure and substrate specificity.
AnaSpec offers two new anti-MMP antibodies.
Anti-MMP-1 (Hinge), Collagenase-1.
Rabbit polyclonal anti-MMP-1 (Hinge) antibody was raised against a synthetic collagenase-1 peptide derived from the hinge region of human MMP-1.
This interstitial collagenase (MMP-1) dissolves extracellular matrix (ECM) and may initiate and promote angiogenesis.
MMP-1 (collagenase 1) is involved in tumour development and metastasis, and rheumatoid arthritis.
Anti-MMP-1 (Hinge) reacts with MMP-1 at the molecular weight of 52kDa as an unglycosylated and 57kDa as a glycosylated pro-form of MMP-1.
Anti-MMP-13 (Hinge), Collagenase-3.
Rabbit anti-MMP-13 (Hinge) polyclonal antibody was raised against a synthetic collagenase-3 peptide derived from the hinge region of human MMP-13.
MMP-13 (collagenase-3) is a member of the MMP family of extracellular proteases.
Targets of MMP-13 include collagen, gelatin, aggracan, plasminogen and CXCL12.
MMP-13 is secreted as a 60-kDa proenzyme (as measured by SDS-Page), and activated by cleavage to a mature 48-kDa MMP-13.
Anti-MMP-13 reacts with MMP-13 at the molecular weight of approximately 60kDa at pro-form and 48kDa at active form on Western blot.
• AnaSpec: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
