Product category:
Nucleic acid sequencing and synthesis
News Release from: Applied Biosystems | Subject: API 2000 and API 3000
Edited by the Laboratorytalk Editorial
Team on 08 September 2005
LC/MS/MS for therapeutic drug monitoring
Researchers at the Institute of Pharmacology, Medical School Hannover, are monitoring blood levels of individually tailored doses of therapeutic drugs
The Hannover researchers are using Applied Biosystems's API 2000 and API 3000 LC/MS/MS systems in their work Volkhard Kaever, head of the therapeutic drug monitoring (TDM) group, explained: "We are using LC/MS/MS techniques for TDM of immunosuppressive, antiviral and antibiotic drugs in our research studies
This article was originally published on Laboratorytalk on 2 Oct 2001 at 8.00am (UK)
Related stories
High throughput nucleic acid purification
Applied Biosystems has released the ABI Prism 6100 nucleic acid PrepStation for high throughput purification of RNA and DNA, taking only 30 minutes to isolate total RNA from cells
"These techniques are widely accepted as the gold standard method for quantification of immunosuppressive drugs, and we are now using them to investigate toxicity of these and antiviral drugs.
"We are also using in vitro and in vivo experiments to try and understand the molecular mechanisms of unwanted side effects of these drugs.
"With the robust and sensitive API 2000 and 3000 LC/MS/MS systems, we can quickly and simultaneously measure four immunosuppressive or nine antiretroviral drugs within a single run, avoiding tedious clean-up times or cross-reactivity issues.
"We can establish LC-online SPE-ESI-MS/MS methods with total analysis times of just a few minutes that effectively manage the matrices.".
• Applied Biosystems: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
