Protein characterisation in solution

Provides measurement of protein heterogeneity, stoichiometry, interacting/self-associating systems and molecular conformation studies for improved lead optimisation

Beckman Coulter recently introduced the ProteomeLab XL-A, XL-I for protein characterisation in solution.

Part of the company's new ProteomeLab family of products, the XL-A, XL-I provides measurement of protein heterogeneity, stoichiometry, interacting/self-associating systems and molecular conformation studies for improved lead optimisation.

The system is ideal for stability testing applications in which drug compound aggregation presents a challenge.

In addition to rigorous characterisation, the XL-A,XL-I technology measures relative changes in the distribution of molecular weights and enables the collection of many simple yes/no answers, for quick and efficient investigations.

"Because the XL-A,XL-I measures proteins as interacting elements instead of in isolation, it provides a more thorough understanding of a drug candidate before it moves into pre-clinical or clinical trials," explains Paul Voelker, strategic marketing manager for Beckman Coulter.

"The real strength of this system is its ability to analyse proteins in solution, under native conditions".

The ProteomeLab XL-A,XL-I offers a choice of detection systems.

The XL-A uses a scanning UV/VIS detection system, while the XL-I is equipped with both scanning UV/VIS and Rayleigh Interference detection systems.

The XL-I can simultaneously collect data from both detection systems to provide the broadest spectrum of data for solution interaction analysis.

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