Product category:
Reagents and catalysts
News Release from: Beckman Coulter | Subject: Phospho-MapKapK-2 and Phospho-Stat3
Edited by the Laboratorytalk Editorial
Team on 27 June 2007
Reagents measure responses to cell
stimuli
By measuring the phosphorylation of specific intracellular proteins, these RUO reagents can aid in the study of surface-to-nucleus cell signal transduction pathways
Beckman Coulter introduces two additions to its line of cell signal transduction reagents - Phospho-MapKapK-2 and Phospho-Stat3 kinase antibodies These single-colour flow cytometric reagents measure kinase activation in the cytoplasm and are valuable for cell function research
This article was originally published on Laboratorytalk on 29 Apr 2008 at 8.00am (UK)
Related stories
Fiberlite rotors added to centrifuge selection
Beckman Coulter announces the addition of two new Fiberlite rotors to its selection for the Avanti J series high-performance centrifuge systems
Quality certification for Quanta flow cytometers
Beckman Coulter announces the Q-Check programme for the company's Quanta SC and Quanta SC MPL flow cytometers, providing tools for installation and operational qualification (IQ and OQ)
The Phospho-MapKapK2 marker is particularly useful in the study of pro-inflammatory mediator release, actin reorganisation and cell invasion mechanisms.
The Phospho-Stat3 marker that translocates to the cell nucleus upon activation plays a key role in many cellular processes such as cell growth and apoptosis.
Flow cytometry is a unique tool for clinical research because it can quantitate activated signal transduction proteins within individual cells.
The technique can carry out these measurements at the same time in two or more signal transduction pathway nodes and can also handle mixed populations of cells and complex samples, including peripheral blood and bone marrow.
The two new reagents can measure kinase activity from whole blood samples.
Beckman Coulter now offers a total of 40 cell signaling reagents, including 15 that are activation state-specific.
"The field of signal transduction research by flow cytometry is relatively new and is growing at an exciting pace".
commented Michel Herbert, research reagents marketing manager for Beckman Coulter.
"The ability to examine and measure cell-by-cell activation states, even in whole blood leucocyte populations, gives us a powerful tool for investigating intercellular functional networking and its related disorders".
Beckman Coulter signal transduction reagents are approved for research use only (RUO), and are not for use in diagnostic procedures. Request a free brochure from Beckman Coulter ...
• Beckman Coulter: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
