Product category:
Lab automation equipment and robotics
News Release from: Caliper Life Sciences | Subject: LabChip systems
Edited by the Laboratorytalk Editorial
Team on 12 May 2008
Cell-based GPCR profiling and lead
optimisation
Caliper Life Sciences announces a collaboration with DiscoveRx that enables functional cell-based G protein-coupled receptor (GPCR) assays from DiscoveRx to be performed on Caliper's LabChip platforms
The combined offering bundles Caliper LabChip systems with DiscoveRx's cellular assays, including PathHunter ss Arrestin and cAMP Hunter, to assist pharmaceutical and biotechnology researchers in more efficiently discovering GPCR drugs "This collaboration will expand the capability of Caliper's LabChip technology into the dynamic GPCR drug discovery market, an opportunity with substantial potential due to the importance of GPCR drugs and the number of active R+D programs in neuroscience, cardiovascular, inflammation and other disease areas"
This article was originally published on Laboratorytalk on 12 May 2008 at 8.00am (UK)
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"Through our collaboration with DiscoveRx, we have expanded our offerings to provide researchers with the ability to prosecute GPCR targets in a functional cellular assay for lead optimization and profiling," said Kevin Hrusovsky, CEO of Caliper Life Sciences.
"Caliper's LabChip platform has become the new standard for kinase assays and we have broadened the platform to enable testing of phosphodiesterases, histone deacetylases (including sirtuins) proteases, phophatases and lipid modifying enzymes".
"The addition of cellular GPCR assays, which are a critical linkage in translational research, expands Caliper's in vitro-in vivo bridge and should provide our customers with enhanced ability to make more informed decisions that ultimately lead to safer and more effective drugs", Caliper's LabChip instruments - the LabChip 3000 and LabChip EZ Reader series - which have been adopted by 17 of the top 20 pharmaceutical and biotechnology companies, utilise proprietary microfluidic separation and direct detection of both substrates and products to generate high quality results.
Further reading
Optical imaging to aid tuberculosis research
Texas A+M Health Science Center Research Foundation (HSCRF) is using Ivis Spectrum imaging system from Caliper Life Sciences to speed development of effective therapeutic treatments for tuberculosis
Bench-top reader automates enzymatic assay work
Caliper Life Sciences has launched the Caliper LabChip EZ Reader series, delivering a complete range of products for in-house kinase profiling
This robust, easy-to-use platform, combined with DiscoveRx's innovative ss-Galactosidase enzyme fragment complementation (EFC) approach for cellular GPCR assays, should provide researchers with the ability to perform more clinically relevant cellular-based assays.
"PathHunter ss-Arrestin assays, HitHunter cAMP detection and now cAMP Hunter cell lines are all being successfully adopted by leading pharmaceutical companies in their GPCR screening campaigns.
"Our partnership with Caliper enables the use of these highly successful cell-based GPCR assays on Caliper's microfluidic technology platform to provide a powerful and comprehensive suite of solutions for Caliper's EZ Reader and kinase profiling customers," said Pyare Khanna, CEO of DiscoveRx.
"Together, we are meeting the demand for GPCR and Kinase lead optimisation and profiling". Request a free brochure from Caliper Life Sciences ...
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