Caliper launches kinase inhibitor services

Caliper Life Sciences (CALP) has announced the availability of two new service offerings from Caliper Discovery Alliances and Services (CDAS), the company's contract research organisation.

These two services, RapidKinase profiling and enzymatic Mechanism of Action studies, both provide valuable resources to researchers looking to better understand the properties of their kinase inhibitor compounds.

The RapidKinase profiling service utilises Caliper's LabChip EZ reader technology and ProfilerPro reagents to provide kinase profiling data to researchers within one week.

The RapidKinase service enables researchers to benefit from the process improvements inherent to ProfilerPro reagents and also reap the organisational, cost and workflow benefits of outsourcing.

Mechanism of Action studies provide researchers with detailed information about the manner in which their compounds interact with enzymatic targets and are important for characterising allosteric inhibitors and assessing kinetic on and off rates.

Allosteric inhibitors, which interact with enzyme targets at locations other than the active site, are important because the compounds with this activity often are in chemical spaces that have fewer competing patents.

Compounds with slow off rates take a longer than normal amount of time to disassociate from the kinase, which allows lower doses to be used for treatments, decreasing the potential for side effects.

The launch of the CDAS RapidKinase profiling services coincides with the availability of more than 200 kinase assays.

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