Product category:
Proteomics
News Release from: Cambridge BioScience | Subject: TranSignal protein/DNA arrays
Edited by the Laboratorytalk Editorial
Team on 27 August 2003
Simultaneous screening of transcription
factors
Arrays can be used to study transcription factor activation in a variety of biological processes including cell proliferation, differentiation, transformation and apoptosis
Cambridge BioScience's range of TranSignal arrays now includes the TranSignal protein/DNA arrays I and II These transcriptional regulation assays can be combined to screen a total of 150 unique transcription factors simultaneously
This article was originally published on Laboratorytalk on 4 Jul 2005 at 8.00am (UK)
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This allows determination of active transcription factors in a cell or tissue sample in a single experiment.
Interactions between multiple transcription factors can also be analysed.
TranSignal protein/DNA arrays simplify the functional analysis of eukaryotic transcription factor.
They have significant advantages over cumbersome gel motility-shift assays which only allow characterisation of a single transcription factors.
The assays are safe, requiring no radiation, and are highly sensitive thanks to improved HRP-based chemiluminescence.
The TranSignal procedure is simple and straightforward.
Each array is spotted with 54-96 different consensus-binding sequences, each corresponding to a specific, highly characterised transcription factor.
TranSignal arrays can be used to study transcription factor activation in a variety of biological processes including cell proliferation, differentiation, transformation and apoptosis.
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