Putting the HP into HPLC

Evaporative light scattering detector is a mass sensitive device which produces a response directly proportional to an analyte's mass in the sample

ESA Analytical has introduced a new modular evaporative light scattering detector for use with HPLC that provides universal detection of non-volatile compounds.

The Chromachem evaporative light scattering detector is a mass sensitive device, which produces a response directly proportional to an analyte's mass in the sample.

Unlike HPLC UV or fluorescence detectors the Chromachem does not require the presence or absence of chromophores, fluorophores or electroactive groups for detection.

The technique is fully compatible with both organic solvent based and aqueous mobile phases, even at high or microbore flow rates (20µl to 3ml/min.).

The Chromachem is ideally suited to the detection of a wide range of weakly chromophoric compounds including lipids, phospholipids, triglycerides, carbohydrates, polymers, pharmaceuticals and combinatorial library compounds.

Incorporating a unique nebulisation system, state-of-the-art electronics, high intensity polychromatic light source and low noise photomultiplier the Chromachem offers sensitivity better than RI or low wavelength UV HPLC detectors.

Insensitive to temperature variation the highly stable Chromachem also provides leading-edge consistency in measurement of relative response factors.

As a consequence direct assessment of relative mass is possible, without standards, saving time and making HPLC-ELSD the most versatile of techniques.

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