Product category:
Chromatographs: liquid, ion, gel, HPLC
News Release from: ESA Biosciences | Subject: Corona CAD detector
Edited by the Laboratorytalk Editorial
Team on 23 February 2005
Technology advances analysis of natural
products
In charged aerosol detection, the HPLC column eluent is first nebulised with nitrogen and the droplets are dried to remove mobile phase, producing analyte particles
ESA has announced four new application notes discussing and illustrating how HPLC using charged aerosol detection (CAD) is providing major advances in the fields of natural product analysis HPLC-CAD is shown to deliver outstanding performance in all of the important criteria necessary for a universal detector for the analysis of ginseng, ginko, black cohosh and soy saponins
This article was originally published on Laboratorytalk on 24 Jul 2008 at 8.00am (UK)
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It says the technique is demonstrated to provide sensitivity to low nanogram levels and to be extremely reproducible.
Typically, charged aerosol detection delivers ten times the sensitivity of evaporative light scattering (ELS), more consistent response factors than LC-MS, UV, or ELS, and the gradient performance missing from RI.
CAD (charged aerosol detection) is said to be a unique technology, in which the HPLC column eluent is first nebulised with nitrogen and the droplets are dried to remove mobile phase, producing analyte particles.
A secondary stream of nitrogen becomes positively charged as it passes a high-voltage, platinum corona wire.
This charge transfers to the opposing stream of analyte particles.
The charge is transferred to a collector where it is measured by a highly sensitive electrometer, generating a signal in direct proportion to the quantity of analyte present.
ESA's Corona CAD detector installs easily with any HPLC system and takes up minimal bench space due to its small footprint.
The Corona is highly versatile and can be easily integrated with existing instruments to analyse virtually any non- or semi-volatile compound.
For a copy of these application notes and further information on this breakthrough in HPLC detection technology, contact ESA. Request a free brochure from ESA Biosciences ...
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