Product category:
Chemicals and biochemicals
News Release from: Genaxxon Bioscience | Subject: Calcineurin B
Edited by the Laboratorytalk Editorial
Team on 20 November 2003
Commercial availability of Calcineurin B
Calcium binding and calmodulin binding protein Calcineurin B is now commercially available for neurosciences and cardiovascular research
Calcineurin is a calcium binding and calmodulin binding protein found in all cells from yeast to mammals It is a calcium dependent, calmodulin stimulated protein phosphatase regulating aspects of both cell wall synthesis and ion homeostasis in yeast cells
This article was originally published on Laboratorytalk on 21 Nov 2003 at 8.00am (UK)
Related stories
Superoxide dismutases for neuroscience research
Superoxide dismutases (Sods) catalyse the disproportionation of superoxide anion radicals to yield molecular oxygen and hydrogen peroxide
Substances for pharmaceutical research
Cytokines are increasingly used in personalised therapy, such as the treatment of bone marrow aplasia as a result of chemotherapy
It also modulates the rate of pheromone-induced Ca2+ uptake and is required to maintain normal vacuolar morphology during prolonged pheromone treatment.
Calcineurin is discussed to be involved in myocardial infarction, stroke, alzheimer's disease, renal diseases, potentation and memory.
Calcineurin B is a heterodimeric Ca2+/calmodulin-dependent protein phosphatase composed of two components (A and B).
The A component is the catalytic subunit and the B component confers calcium sensitivity.
Genaxxon says it is proud to have access to the first commercial source for this important protein in its recombinant human origin.
The phosphatase is expressed in E coli and equals the native, full-length human CnB.
The molecular weigth of CnB is 19.3 kDa.
The purity of the delivered enzyme is >90% (by SDS-Page).
Since it is a recombinant protein you don't have to deal with potentially biohazardous material of human origin.
With the availability of Calcineurin in larger quantities, research groups can launch new approaches towards the investigation of functional methods of oxidative stress, neurodegeneration, stroke and cardiovascular diseases.
• Genaxxon Bioscience: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
