Product category:
Reagents and catalysts
News Release from: Haematologic Technologies | Subject: SBIR grant
Edited by the Laboratorytalk Editorial
Team on 31 March 2005
Measuring murine coagulation levels in
plasma
Assays and reagents developed through phase II grant will give researchers experimenting with murine models more tools for their research, and allow for more complicated analytical studies to be done
Haematologic Technologies (HTI) has been awarded a phase II SBIR grant application to research and manufacture mouse coagulation proteins, anti-murine antibodies and related immunoassays The grant, from NIH, will allow HTI to add to its current line of mouse coagulation factors and antibodies, and use them to create Elisas to measure murine coagulation factor levels in plasma
This article was originally published on Laboratorytalk on 10 Nov 2003 at 8.00am (UK)
Related stories
Murine coagulation reagents are a knockout
These reagents will give researchers doing experiments with knock-out and transgenic mice more options and allow for more complicated analytical studies to be done
Manufacturing process for Parkinson's drug
First discussion of the novel production approach used for ProSavin, a LentiVector-based product, to be made at Bio 2003 this week in Washington DC.
Nicholson Metabolic Pathways go online
Simple yet comprehensive schematic of how nutrients are utilised to produce the energy and biochemicals essential for the growth, mobility, reproduction and survival of living things
These assays and reagents will give researchers experimenting with murine models more tools for their research, and allow for more complicated analytical studies to be done in this field.
Background.
The mechanisms that govern blood coagulation and fibrinolysis have been studied extensively by employing a variety of experimental techniques and in-vivo model systems.
Recently gene targeting (knock-out mice) and transgenic techniques have been employed to create strains of mice whose phenotypes represent human thrombotic disorders and disease states.
In conjunction with this, murine coagulation models are routinely used in the process of new drug development.
During the course of developing new pro-coagulant, anti-coagulant and clot dissolving drugs, basic R and D studies as well as safety, efficacy, and pharmacokinetic studies are required.
Because both normal and genetically altered mice are available, the murine models are ideal for this application.
Based on the fact that murine models are in prevalent use, and there exists a limited number of reagents available to assist the researcher, it is imperative to develop a commercial group of reagents for use in this field of study.
Haematologic Technologies will continue its R and D efforts on its murine line by focusing on generating reagents and assays analogous to what is available for human research.
• Haematologic Technologies: contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
