Product category:
General lab equipment
News Release from: Harvard Apparatus | Subject: Moist Chamber type 834/8
Edited by the Laboratorytalk Editorial
Team on 10 March 2008
Organ chamber for optimised DMPK studies
The Moist Chamber type 834/8 increases efficiency and accuracy of dosing and metabolic studies in isolated organs such as kidney and liver from small rodents
A flexible silicone platform within the chamber doubles as a surgery table for isolation and cannulation of the organ The cannulation procedure is simplified through the use of the integrated Mini Ball Joint positioning system and purpose-built arterial and venous cannulae
This article was originally published on Laboratorytalk on 12 Feb 2008 at 8.00am (UK)
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Organ chamber mimics physiological conditions
The Moist Chamber type 834/8 from Harvard Apparatus is described as an exceptionally flexible and useful tool for perfusion of organs such as liver and kidney from typical rodent models
An extra access port is integrated into the base of each cannula for direct dosing upstream of the organ or sampling of the effluate downstream.
In addition, several measurement and sample ports are milled through the chamber wall for easy access to the inner chamber.
These innovations permit the researcher to measure a range of physiological, pharmacological and metabolic parameters while maintaining the organ in a closed, controlled environment.
The Moist Chamber type 834/8 can be part of a simple constant flow perfusion system for testing potential vasoactive compounds, or used to form the core of a combined constant pressure / constant flow perfusion system for more complex perfusion and dose-response regimens.
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