Orgnic chemistry coupling reagent

Edited by the Laboratorytalk editorial team Mar 9, 2004

Assisting typical amide syntheses requiring a DCM/DMF solvent mixture, Actu addresses the problem that many carboxylic acids of interest are not soluble in DCM

Argonaut's Actu coupling reagent allows polymer-supported active esters of PS-HOBt(HL) to be prepared in DMF.

Assisting typical amide syntheses requiring a DCM/DMF solvent mixture, Actu addresses the problem that many carboxylic acids of interest are not soluble in DCM.

In alternative syntheses performed in DMF using PS-Carbodiimide with HOBt as the additive, Actu complements the method by providing the additional advantage that the product amide is usually formed in a low-boiling point solvent thus avoiding having to isolate the product from DMF.