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News Release from: Lab21 | Subject: K-ras gene test
Edited by the Laboratorytalk Editorial
Team on 25 January 2008
Cancer gene testing service launched by
Lab21
Lab21, a provider of health and environmental diagnostics, is providing a test for analysis of the K-ras gene from its Cambridge laboratories
K-ras plays an important role in cell growth regulation and the proliferation of cancer cells In around 40% of cancer patients the K-ras gene is mutated and the resulting protein can limit the effectiveness of cancer therapies
This article was originally published on Laboratorytalk on 26 Jul 2005 at 8.00am (UK)
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By identifying cancer patients with mutated K-ras, clinicians can quickly identify the most effective treatment.
Patients with the mutated K-ras gene can be given alternative treatments, improving their chances of successful treatment.
Although the presence of wild-type K-ras does not guarantee that a patient will respond, identification of those patients who will not respond is equally important because it saves the patient exposure to potential drug toxicities as well as expense.
This form of personalised medicine whereby drugs are tailored to the genetic background of the target patient is becoming more important as more drugs are being developed which have clinical benefits for these specifically targeted patients.
Lab21 specialises in the provision of personalised medical services to both the private and public sector and is now launching a fully-approved commercial K-ras testing service.
Graham Mullis, CEO of Lab21 explained: "As new technologies develop to assist in cost-effective and efficient use of drugs, the need for prospective analysis of patient samples in high quality reference laboratories will become increasingly more important.
"At Lab21 we are committed to building a portfolio of new tests, particularly in the oncology area, which can provide rapid results for cancer patients and help practitioners to direct more efficient treatment.
"Being able to select which patients are more likely to respond to therapy is an important step forward in the treatment of cancer".
For example, scientists have shown recently that cetuximab, a new treatment for colorectal cancer, is poorly responsive if the tumours carry a mutated K-ras gene.
Similarly, mutations in K-ras also confer resistance to erlotinib, a small molecule treatment for lung cancer.
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