Product category:
General lab equipment
News Release from: Labtex | Subject: Ramos
Edited by the Laboratorytalk Editorial
Team on 05 April 2006
'Ground-breaking' development in
biotechnology
For the first time this special measuring method allows optimisation of bioprocesses by online-measurement of the respiration activities of cultures, including mammalian cells in shaking flask
The purpose of the Ramos respiration activity monitoring system is to allow real-time estimation of key processes variables such as OTR (oxygen transfer rate) and RQ (respiratory quotient) etc Normally, a stirred tank fermenter system with exhaust gas analysis would be required to acquire this information
This article was originally published on Laboratorytalk on 30 Sep 2005 at 8.00am (UK)
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This can be an expensive, time consuming solution requiring a lot of space.
If this work can be done more rapidly, with less use of resources and at an earlier stage of process development the potential savings are easy to appreciate.
The major benefits of the Ramos system are the compact set-up and the easy handling.
The computer controlled device is fully automatic.
There are many fields of application:.
Tracing of the proliferation rate of pro and eukaryotic cultures under sterile conditions.
Easy determination of characteristic values for scale up (OTR, CTR, RQ, umax, kLa).
Bioprocess optimisation through early identification of oxygen and substrate limitation or product inhibition.
Bioassays (toxicity assay, proliferation assay).
Development of suitable conditions in the primary and secondary screening (culture duration, media, operating conditions).
Identification of changes in metabolism (e.g diauxic growth, fermentation).
Mass balance of fermentation processes.
Ramos was developed in cooperation with the department of biochemical engineering (Aachen University of Technology) and is a patented design offering distinct advantages over traditional fermentation systems.
More information about your microbiological processes in shaking flasks.
Easy handling.
Rapid characterisation and targeted optimisation of media.
Shortens the time-to-market.
Replaces expensive experiments in the fermenter.
Identical cultivation conditions as in your shaking flask.
Parallel technology (time, comparability).
Reduction of development time for bioprocess and cultivation conditions.
Provides optimum screening conditions.
Allows reproducible inoculums.
Virtual non-stop operation by extremely short set-up time.
Reduction of experiment time to the actually required time.
Distinction of process-related and biological. Request a free brochure from Labtex ...
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