Product category:
Particle size analysis equipment
News Release from: Malvern Instruments | Subject: Spraytec
Edited by the Laboratorytalk Editorial
Team on 23 January 2007
Work on aerosolisation presented at DDL
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At the Drug Delivery to the Lungs conference Paul Kippax, product manager for diffraction systems at Malvern Instruments, presented collaborative work on the aerosolisation of powders for inhalation
This work involved the use of the Malvern Spraytec particle size analyser to examine the time dependence of powder release from a dry powder inhaler (DPI) It was carried out in collaboration with David Morton, a recognised expert in the development of inhalation systems
This article was originally published on Laboratorytalk on 24 Jun 2008 at 8.00am (UK)
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Melbourn is first UK CRO to routinely use Spraytec
Melbourn Scientific has become the first CRO in the UK to routinely use the Malvern Instruments Spraytec particle size analyser to support the development of inhaler, nebuliser and nasal spray systems
Aiming to make vaccine delivery pedal-powered
Researchers at Aerovax, at MIT, are using the Spraytec particle size analyser from Malvern in the development of an innovative platform for vaccine delivery, intended for use in developing countries
The results demonstrate the value of the Malvern Spraytec as a screening tool for optimal inhaler design.
The interactions between a drug-containing powder formulation and an inhaler device are notoriously complex, and traditional techniques for their study have recognised limitations.
With the Spraytec system the time-dependence of the dose delivered can be measured rapidly for different formulations, providing reliable information for product optimisation.
In addition, the impact of various inhaler device characteristics can be assessed.
One conclusion from the work was that the Spraytec system provided improved insight into the mechanisms governing powder plume evolution.
It made possible the study of how the concentration of the plume changed over time during actuation, enabling a clearer understanding of the factors influencing the process of powder entrainment and dispersion.
It is expected that use of the Spraytec will accelerate product development and also the generation of successful formulations targeting specific areas of the respiratory system.
The Spraytec features an inhalation cell that is designed specifically for drug delivery applications.
It enables measurements to be carried out under fixed or varying flow conditions.
A data acquisition rate of 10kHz coupled with a wide dynamic range allows the delivery profiles of both fine drug particles and coarser excipients to be captured simultaneously in exceptional detail.
Understanding the interactions between different components of a formulation is crucial to developing a product with the required dispersion characteristics. Request a free brochure from Malvern Instruments ...
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