Sonication for high throughput systems
A
Matrical product story
Edited by the Laboratorytalk editorial team
Nov 4, 2004
Pinned lid design enables sonication of 96- and 384-well microwell plate formats with disposability to prevent cross-contamination
MatriCal introduces the SonicMan high throughput sonication system for 96 and 384-well microwell plate formats.
Applications of the SonicMan include resuspending stored compounds in HTS; resolubilising compounds in synthesis; shearing genomic data into small fragments for PCR amplification; extracting target proteins, RNA/DNA, and enzymes via cell lysis and membrane disruption; mixing low volume assays; driving sonochemical reactions; and transfecting eukaryotic cells.
"The SonicMan demonstrates how a massively parallel sonication system designed to work in 96/384/1536 formats can be used to drive compounds back into solution," explains Kevin Oldenburg, president of MatriCal.
This technology relies on a pinned lid that is placed on a microplate (96 or 384 well).
The pins insert through the lid and into the sample contained within the plate.
A sonic horn is brought into contact with the lid and the sonic energy is transferred into the sample.
As scientists are highly conscious of cross contamination, the lid has been developed as a disposable part.
The pinned lid is designed to ensure sample integrity with no well-to-well cross contamination.
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