Avian transgenic results in scientific journal
An
Oxford BioMedica product story
Edited by the Laboratorytalk editorial team
Jan 17, 2007
PNAS has published an article profiling the avian transgenic (Ova) system's ability to express two therapeutic proteins in the whites of eggs of transgenic hens
Oxford BioMedica and its collaborative partners in the field of avian transgenics, Viragen and Roslin Institute, report that the Proceedings of the National Academy of Sciences of the United States of America (PNAS), a leading scientific journal, has published an article profiling the avian transgenic (Ova) system's ability to express two therapeutic proteins in the whites of eggs of transgenic hens.
The Ova System is being developed as a novel, large-scale biomanufacturing alternative, capable of cost-effectively expressing many types of therapeutic proteins.
The article, entitled, 'Oviduct-specific expression of two therapeutic proteins in transgenic hens', reports on the production of two protein drug candidates: a humanised monoclonal antibody being developed by Viragen for advanced malignant melanoma and interferon beta-1a, which is currently marketed under two competing brand names for the treatment of multiple sclerosis (MS), as Avonex (Biogen Idec) and Rebif (Serono).
Article summary: Recent advances in avian transgenesis have led to the possibility of utilising the laying hen as a production platform for the large-scale synthesis of pharmaceutical proteins.
Ovalbumin constitutes more than half of the protein in the white of a laid egg, and expression of the ovalbumin gene is restricted to the tubular gland cells of the oviduct.
The authors describe the use of lentiviral vectors to deliver transgene constructs comprising regulatory sequences from the ovalbumin gene designed to direct synthesis of associated therapeutic proteins to the oviduct.
They report the generation of transgenic hens that synthesise functional recombinant pharmaceutical protein in a tightly regulated tissue-specific manner, without any evidence of transgene silencing after germ-line transmission.
According to Viragen vice president, Karen Jervis, who is managing director of Viragen's Scotland operations, additional avian transgenic milestones are expected shortly: "We are very pleased that the PNAS article chronicles our 'proof-of-principle' studies resulting in successful germline transmission of two therapeutic proteins, and we expect to report excellent new results with a third protein-drug candidate by the end of this month, assuming positive confirmations".
Professor Alan Kingsman, Oxford BioMedica's chief executive officer commented: "We are delighted by the progress of our collaborative partners towards the commercialisation of the OVA System.
"This technology could address a substantial need in the biopharmaceutical industry for efficient, high-volume production of biological products.".
Not what you're looking for? Search the site.
Google Ads
Contact Oxford BioMedica
Related Stories
- 454 Genome Sequencer reaches milestone
- SeqWright joins genetic heart disease study
- UK Young Life Scientist Award winner announced
- Protein Forest addresses proteomics 'shortcomings'
- New Roche lab will reduce need for animal testing
Articles by product category
-
Analytical instruments (8,805)
- Analytical instruments (13)
- Chemical analysis equipment (631)
- Chromatographs: gas (241)
- Chromatographs: liquid, ion, gel, HPLC (427)
- Chromatography accessories (503)
- Gas analysis equipment (219)
- pH and conductivity meters (114)
- Cameras and imaging systems (820)
- Electron microscopy systems (209)
- Optical microscopes (448)
- Microscope supplies and accessories (558)
- Mass spectrometers (458)
- Spectroscopy (535)
- Other analytical instruments (592)
- Particle size analysis equipment (555)
- Microplate readers (39)
- Temperature, pressure and flow measurement (262)
- Spectrophotometers (273)
- Titration equipment (655)
- Ultrasound equipment and ultrasonic spectroscopy (118)
- Viscometers and rheometers (346)
- Oscilloscopes (83)
- Mechanical testing equipment (492)
- Test and calibration instrumentation (214)
-
Life sciences and clinical laboratory equipment (3,579)
- Life sciences and clinical laboratory equipment (3)
- Clinical chemistry analysis (898)
- Nucleic acid sequencing and synthesis (637)
- Genomics (459)
- Proteomics (450)
- Assay kits (185)
- Microbiology (383)
- Polymerase chain reaction (PCR) (240)
- Cell/tissue handling and counting (324)
-
Computer hardware (826)
- Computer hardware (7)
- Dataloggers (302)
- I/O devices (362)
- Monitors and peripherals (50)
- Process control and networking (79)
- PLCs (26)
-
Industry news (19)
- Industry news (19)
-
Laboratory equipment and wares (5,937)
- Laboratory equipment and wares (5)
- Safety and ventilation equipment (322)
- General lab equipment (831)
- Workstations (61)
- Detectors, sensors and probes (375)
- Lab automation equipment and robotics (651)
- Laboratory furniture and storage (151)
- Gas handling (125)
- Heating: ovens, furnaces, autoclaves (331)
- Fermentation and incubation equipment (73)
- Microplates/microarrays and readers (397)
- Microfluidics/Lab-on-a-chip systems (142)
- Distillation equipment (16)
- Sampling equipment (156)
- Environmental chambers (88)
- Fume cupboards ductless (79)
- Laboratory glassware (400)
- Liquid handling (415)
- Cooling: refrigeration (198)
- Washing and sterilisation equipment (207)
- Fume cupboards ducted (31)
- HTS and combinatorial chemistry equipment (57)
- Evaporation equipment (166)
- Weighing and balancing (240)
- Centrifuges (47)
- Water purification (213)
- Laboratory plasticware (160)
-
Laboratory supplies and consumables (1,271)
- Laboratory supplies and consumables (2)
- Culture media (119)
- Reagents and catalysts (169)
- Antibodies (203)
- Cleaning products (65)
- Reference standards (178)
- Chemicals and biochemicals (534)
-
Pumps, Valves, Filters (708)
- Automated Valves (66)
- Filtration equipment and supplies (176)
- Metering pumps (109)
- Other pumps (63)
- Peristaltic pumps (65)
- Vacuum pumps and compressors (144)
- Manual Valves (85)
-
Services (2,989)
- Contract research (889)
- Laboratory and scientific exhibitions and conferences (230)
- Laboratory and scientific recruitment (26)
- Laboratory and scientific consultancy services (288)
- Laboratory and scientific training and education (413)
- Laboratory building and design (50)
- Laboratory and scientific manufacturing services (136)
- Laboratory and scientific professional organisations (482)
- Laboratory and scientific books and publishing (475)
-
Computer software (2,882)
- Computer software (4)
- Chemical modelling software (181)
- Laboratory and scientific databases (327)
- Instrument control software (320)
- Laboratory information management system (LIMS) (721)
- Mathematical software (163)
- Process control and networking software (52)
- Data acquisition software (171)
- Chromatography software (284)
- Spectroscopy software (92)
- Analytical, statistical and report generating software (284)
- Data management software (283)
