Product category:
Mass spectrometers
News Release from: Perkin Elmer LAS (UK) | Subject: Spectrum Spotlight
Edited by the Laboratorytalk Editorial
Team on 18 January 2002
Active ingredient analysis
PerkinElmer's Spectrum Spotlight FT-IR system has the sensitivity to provide rapid measurement and high quality results for active ingredient analysis in solid-phase drug delivery systems
Spectrum Spotlight is ideally suited to pharmaceutical quality control requirements, including the analysis and characterisation of time-release drug delivery systems These are increasingly important in modern pharmaceuticals, avoiding the need for repeated injections, and ensuring a more constant delivery of drug
This article was originally published on Laboratorytalk on 3 Sep 2004 at 8.00am (UK)
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This is particularly significant where the difference in concentration between therapeutic and toxic drug levels is quite small.
Such drug delivery systems are often based on a selected polymer or 'depot' within which the drug is included.
The identification and distribution of the active ingredient throughout the depot is critical to manufacturing quality control of the product.
A new application note describes the use of the Spectrum Spotlight to analyse a sample of a typical drug delivery system.
Illustrations include a visible image and a total absorbance map of the sample, as well as raw and Kramers-Kronig treated spectra showing both the carrier polymer and the active ingredient.
Active ingredient distribution through the depot can clearly be analysed, allowing accurate quality control of the drug delivery implant.
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