Product category:
Polymerase chain reaction (PCR)
News Release from: Qiagen | Subject: HP OnGuard
Edited by the Laboratorytalk Editorial
Team on 26 October 2006
HP OnGuard siRNA design ensures
successful RNAi
SiRNA design is reinforced using the results from Qiagen's siRNA validation project in which thousands of siRNAs have been tested for effectiveness by real-time RT-PCR
HP OnGuard siRNA design from Qiagen is an upgrade to the HiPerformance siRNA design algorithm It uses advances in the knowledge of the RNAi mechanism to reduce the risk of off-target effects and increase potency, ensuring successful RNAi
This article was originally published on Laboratorytalk on 20 Aug 2001 at 8.00am (UK)
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HP OnGuard siRNA design incorporates an innovative neural-network algorithm, proprietary homology analysis, and exciting, newly added features.
Design features include 3' UTR/seed region analysis, SNP avoidance, and interferon motif avoidance.
siRNA design is reinforced using the results from Qiagen's siRNA validation project in which thousands of siRNAs have been tested for effectiveness by real-time RT-PCR.
Data from Affymetrix GeneChip analysis is used to minimise the potential for off-target effects.
As well as siRNAs designed using HP OnGuard siRNA Design, matching RT-PCR assays, RNAi controls, and products for transfection and downstream analysis are available at GeneGlobe, covering the entire RNAi workflow.
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