Product category:
Spectrophotometers
News Release from: Sirius Analytical Instruments
Edited by the Laboratorytalk Editorial
Team on 25 June 2003
Success in Hungary
Semmelweis University becomes the first laboratory in Hungary to deploy Sirius's latest spectrophotometric technology
The longstanding relationship between Sirius Analytical Instruments and Semmelweis University, Budapest, has been strengthened by a contract to purchase the latest Sirius c with D-Pas technology Founded in 1769, Semmelweis University is Hungary's longest established university of health science
This article was originally published on Laboratorytalk on 20 Dec 2002 at 8.00am (UK)
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Rapid pKa measurement
A new automated instrument for rapid measurement of pKa during early stage pharmacokinetic tests has been introduced by Sirius Analytical Instruments
'Gold-standard' for pKa and logP measurement
Used in pharmaceutical laboratories to measure physicochemical properties, which profoundly affect the behaviour of drugs and other ionisable molecules
Its Institute of Pharmaceutical Chemistry has been long associated with Sirius in academic collaboration about spectrophotometric determination of acid dissociation.
Krisztina Takács-Novák leads a research group in the institute and has published many papers in this field.
Dr Takács-Novák helped to validate the UV spectroscopic methodology for pKa measurement that is at the heart of Sirius's D-Pas accessory.
This fundamental research led to three joint publications.
On the basis of this work, Takács-Novák secured corporate financing for the Institute to upgrade its installation to the very latest physicochemical profiling system, and Sirius installed the state-of-the-art GLpKa with D-Pas in January 2003.
The pharmaceutical chemistry department has been a long time user of Sirius's first instrument, the PCA101 that was the forerunner to the GLpKa.
Data from this equipment has been appearing in refereed journal articles since 1994.
The GLpKa uses pH-metric analysis to measure pKa and log P values.
D-Pas offers the user the ability to employ spectrophotometric analysis that is ideally suited to compounds with low solubility.
The GLpKa and D-Pas hardware coupled with Sirius's RefinementPro software suite maximises data quality, accuracy and reproducibility.
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