Accurately identifying unique proteins on 2D gels
A
Syngene product story
Edited by the Laboratorytalk editorial team
Jun 15, 2006
Syngene reports that a Syngene automated multi-functional imaging system is being used by a leading US pharmaceutical company to help increase the pace of discovering novel protein drug targets
Researchers at the pharma major are using the Syngene imaging system to automatically assess around 150 2D protein gels per week.
These gels are up to 26x26cm and are stained with dyes including Sypro Orange, Sypro Ruby, Sybr Green, Coomassie Blue and Pro-Q Diamond.
This is helping the scientists at the company to rapidly identify unique proteins associated with a number of debilitating human conditions including arthritis and heart disease.
A senior scientist at the US pharma said: "The high resolution images the Syngene imaging system produces is enabling us to locate nanogram quantities of unique proteins on gels, which can have as many as 2500 different protein spots on them.
"We installed the Syngene imaging system because it is the only one which is flexible enough to accommodate our Clare Chemical's Dark Reader, as well as allow us to accurately image very large gels stained with lots of different types of dyes.
"Around 13 people use the system routinely not just for gels but for Western blots too.
"Syngene is very responsive with their support and service of the system and because we are so pleased with its performance we have installed a second Syngene imaging system," continued the scientist.
Laura Sullivan, Syngene's divisional manager, commented: "We are excited to see a Syngene system being used in drug discovery research at one of the world's leading pharma companies.
"The levels of sensitivity the researchers are achieving using both visible and fluorescent proteomics dyes confirms that for analysing 2D protein gels a Syngene imaging system is an effective alternative to laser-based scanners.".
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