Product category:
Laboratory information management system (LIMS)
News Release from: Thermo Fisher Scientific (Informatics) | Subject: Galileo Lims at Pfizer poster
Edited by the Laboratorytalk Editorial
Team on 31 October 2006
Poster describes high throughput data
processing
Thermo and Pfizer Global Research and Development co-present a new technical poster demonstrating the use of Galileo Lims for the automation of high throughput data processing for Admet profiling
Galileo Lims is an integrated informatics solution designed specifically for in vitro Admet profiling The poster, to be presented at AAPS, October 29 - November 3, 2006, discusses reasons Pfizer selected a dedicated Lims to address in vitro Admet data and to broadly disseminate that information for maximum use throughout its organization
This article was originally published on Laboratorytalk on 4 Aug 2008 at 8.00am (UK)
Related stories
Data management for the mining industry
Thermo Fisher Scientific says its laboratory information management systems (Lims) offer efficiencies, improved productivity and regulatory compliance for the modern mining industry
Watson Lims for Veeda Clinical Research
Veeda Clinical Research has selected its Thermo Scientific Watson Lims to automate its laboratory processes in its bioanalytical research facilies in Ahmedabad, India and Oxford, UK
Entitled, 'Use of a data management system to handle data processing, storage and uploading for in vitro Adme data in drug discovery', the poster was authored by researchers at Pfizer Global Research and Development, departments of pharmacokinetics dynamics and metabolism and research informatics, as well as product developers at Thermo.
The presentation focuses on advantages the Lims provides in enhancing the value of acquired data by ensuring consistency in the Adme calculations and facile uploading to corporate databases for broad dissemination and impact.
"Historically, lack of a single, consistent approach for calculating, collecting and reporting in vitro Adme data resulted in multiple systems to upload data into global data warehouses from multiple in-house developed systems," said Cornelis Hop, senior director at Pfizer.
Further reading
On the hunt for a large-scale Lims
Hunt Biobank has selected Thermo Scientific Nautilus Lims for one of the largest population-based health studies ever undertaken, with about 100,000 participants from Norway
Thermo's 2008 lab informatics symposium in China
Thermo Fisher Scientific has scheduled its 2008 Laboratory Informatics Symposium (LIS) to take place on 9-10 July 2008 at the Sheraton Dameisha Resort in Shenzhen, China
"Thus, a comprehensive data management system is needed to enhance data handling, processing and uploading to corporate databases".
The poster discusses the importance of Admet profiling for efficient drug candidate selection and optimisation.
It further highlights the challenges facing the high throughput drug discovery laboratories when managing data from a large numbers of compounds and a wide variety of in vitro Admet screening assays and methods.
The poster also provides an overview of the data processing capabilities of Thermo's Galileo Lims.
Galileo Lims is capable of rapidly designing, calculating and reporting in vitro absorption, metabolism, inhibition and kinetic Adme data in an automated manner.
The raw LC-MS data can be imported via rapid study entry using a simple, single dialogue form, thus creating new studies and projects on-the-fly and populating the templates' design with study data.
Adme parameters are flagged with green, yellow or red flags indicating acceptable, questionable or rejected results for each drug candidate.
Galileo Lims also features an 'IC50 shift', a new experiment type to elucidate enzyme inactivation, while it also offers support for Pampa permeability studies that are important in early screening of compounds.
The new technical presentation is available free of charge in hard copy format or as a downloadable PDF. Request a free brochure from Thermo Fisher Scientific (Informatics) ...
• Thermo Fisher Scientific (Informatics): contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
