Product category:
Laboratory information management system (LIMS)
News Release from: Thermo Fisher Scientific Informatics | Subject: Galileo Lims
Edited by the Laboratorytalk Editorial
Team on 12 July 2007
In vitro Adme/Tox profiling and
screening poster
Thermo Fisher Scientific announces the availability, gratis, of a new technical poster demonstrating the use of its purpose-built Thermo Scientific Galileo Lims to perform in vitro Adme/Tox profiling
Galileo Lims provides an integrated, template-driven database system to allow rapid data review and acceptance for large numbers of compounds for a range of Adme/Tox profiling and screening applications such as metabolic stability, IC50, Caco-2 and Pampa It enables pharmaceutical and CRO companies to manage data efficiently and appropriately in order to rapidly execute key decisions on drug candidate selection
This article was originally published on Laboratorytalk on 31 Oct 2006 at 8.00am (UK)
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Adme/Tox profiling has become increasingly important for efficient drug candidate selection and optimisation of a compound's physicochemical properties.
Point solutions such as standalone spreadsheet and graphing tools are inefficient, prone to errors and lead to inconsistent results.
Template modifications propagated over time cause variations in data handling and problematic 'apples to apples' comparisons.
Further reading
Lims enhanced by visualisation and automation
Latest release of laboratory information management system aimed at the demanding high-throughput environment of in vitro Adme/Tox discovery laboratories
Watson Lims for Veeda Clinical Research
Veeda Clinical Research has selected its Thermo Scientific Watson Lims to automate its laboratory processes in its bioanalytical research facilies in Ahmedabad, India and Oxford, UK
The lack of a central repository results in data being maintained in disparate locations without traceability.
A fully functional database system can reduce effort and manpower required and increase throughput by automating complex experiment templating, instrument interfacing, data analysis as well as review and acceptance tasks.
Thermo Scientific Galileo Lims provides simple, easy-to-use data processing, graphing, data review and reporting while also facilitating consolidation and automation of multiple processes.
Furthermore, flexible calculation settings enable laboratories to follow their standard procedures.
Experimental set-up is fast and easy requiring no programming.
Moreover, the system is capable of performing automatic re-calculation after outlier data is removal.
User-definable calculations using Microsoft Excel spreadsheets are controlled and stored securely in Galileo Lims database, adding security and allowing GLP compliance if necessary.
Users are allowed to set up their own tree-style logic for flagging of results.
The study design of Thermo Scientific Galileo Lims templates allows specification of key experimental variables including drug and inhibitor concentrations, species, biomatrix, tissue, analytical time points, assay methods and result calculation options.
Manual data transfer to external software for processing and storage is virtually eliminated.
Instrument data can be rapidly imported via Rapid Study Entry using a simple dialogue to populate the template with analytical results and hence automatic calculation of Adme/Tox parameters.
The system's gallery presents data in tabular, thumbnail or detailed views.
The thumbnail view allows users to scan quickly across many datasets while the details view allows users to 'drill-down' into a data set.
Results are automatically calculated when the charting galleries are opened and re-calculated whenever outlier points are deactivated.
Adme/Tox parameters can be flagged automatically in the gallery or in the details view using green, yellow or red flags to indicate acceptable, questionable or rejected results for each drug candidate. Request a free brochure from Thermo Fisher Scientific Informatics ...
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