Product category:
Chemical analysis equipment
News Release from: Thermo Fisher Scientific (Elemental Analysis) | Subject: ARL X'tra
Edited by the Laboratorytalk Editorial
Team on 22 April 2005
X-ray diffraction for pharmaceutical
analysis
Innovative detector technology enables this powder X-ray diffractometer to perform qualitative and quantitative analyses in central and QA/QC laboratories with high sample throughput
Thermo Electron's ARL X'tra high performance powder X-ray diffractometer (XRD) is described as a state-of-the-art solution dedicated to conducting cost-effective, fast and reliable pharmaceutical analyses of powder samples and tablets in small quantities Incorporating innovative detector technology for rapid data acquisition, the ARL X'tra is designed to perform qualitative and quantitative analyses in central and QA/QC laboratories with high sample throughput
This article was originally published on Laboratorytalk on 8 Aug 2006 at 8.00am (UK)
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X-ray powder diffraction is extensively used in the drug discovery, design, development and formulation processes to obtain valuable knowledge about pharmaceutical products.
The technique allows the scientist to easily identify drug morphology and its degree of crystallinity.
It also facilitates polymorph identification, quantification of phases in a mixture and their behaviour as a function of temperature, humidity and other environmental conditions.
The Thermo ARL X'tra features high angular resolution, which can detect peak overlaps for all types of crystallography analysis thus achieving peak indexing and structure refinement.
Being highly sensitive, the instrument performs quantitative analyses on polymorphs including trace phases.
It also achieves percent crystallinity of fillers, polymorph identification using high and low temperature stages and sample stability using an environmental chamber.
The Peltier cooled Si(Li) solid state detector ensures that the ARL X'tra achieves high sensitivity and superior resolution, while its Bragg Brentano Theta guarantees easy sample handling and flexible geometry.
The instrument's low intrinsic noise allows trace phase identification.
A dual wavelength mode operation means that Cu Ka or Cu Kb can be selected via software depending on the sample type.
Accessories and geometries are easily changeable due to impressive plug and play features.
There is no need to use beta filters and monochromators to remove sample fluorescence or unwanted tube lines.
Standard-less quantitative phase analysis is performed based on Rietveld programs.
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