Product category:
Glass/plasticware
News Release from: Takao | Subject: Precision glass vessels
Edited by the Laboratorytalk Editorial
Team on 09 August 2004
Precision glass vessel for drug
dissolution test
A novel integrated glass fabrication technology is claimed to create the finest and most elaborate glass vessels in the world
Takao Manufacturing says that the differences of bottom curvature and the inner surface irregularities of vessels are critical factors causing erroneous dissolution results The technical limitations of conventional glass processing mean that it is practically impossible to develop glass vessels with a uniform inner shape
This article was originally published on Laboratorytalk on 10 Jan 2003 at 8.00am (UK)
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Now, however, a unique glass fabrication technology allows for the creation of the most precise and accurate glass vessels in the world, says Takao.
The high precision glass vessels are said to possess outstanding characteristics, such as a tenfold improvement in sphericity, circularity, concentricity, cylindricity and tolerance of inside dimensions.
Unevenness observed on the inner surface of conventional glass vessels is almost completely eliminated in the high precision vessels.
The high precision vessel ensures the vertical centre of vessel, which is a critical factor to generate accurate dissolution data.
The dissolution test utilising Prednisone tablet demonstrates that the range of minimum to maximum mean dissolution data in the high precision vessel was one third of that in conventional glass vessel.
The range of variability obtained from the high precision vessels was not more than half of that from conventional vessels.
The variation of dissolution data was markedly decreased by utilising the high precision vessels.
It has long been reported that non-uniformity of inside bottom curvature and inner surface irregularity of vessel cause dissolution results to differ significantly.
A solution to such large variation of dissolution data was provided by the high precision glass vessel.
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