Product category:
Mass spectrometers
News Release from: Thermo Fisher Scientific (Mass Spectrometry) | Subject: Electron transfer dissociation (ETD)
Edited by the Laboratorytalk Editorial
Team on 07 April 2006
License for electron transfer
dissociation (ETD)
Thermo Electron makes agreement with University of Virginia for electron transfer dissociation (ETD), an ion fragmentation technology that provides sequence information on ion trap mass spectrometers
Ken Miller, product marketing manager for proteomics at Thermo, stated: "ETD is an application that benefits immensely from the large ion storage capacity and fast cycle time of Thermo's Finnigan LTQ linear ion trap mass spectrometer" "As a result, we fully expect ETD to be available for this instrument before the end of 2006." According to Miller, the power of ETD on the Finnigan LTQ has already been demonstrated for 1) mapping of post-translational modification (PTM) sites, particularly phosphorylation, 2) allowing more comprehensive proteomic sample profiling than with collision-induced dissociation (CID) alone, and 3) fragmenting and analyzing large peptide fragments as well as intact proteins
This article was originally published on Laboratorytalk on 27 Feb 2007 at 8.00am (UK)
Related stories
Protein and peptide analysis on ion trap mass spec
Thermo Fisher Scientific has unveiled the Thermo Scientific LTQ XL linear ion trap mass spectrometer equipped with electron transfer dissociation (ETD)
Extending LTQ Orbitrap performance in proteomics
The Thermo Scientific LTQ Orbitrap hybrid series of mass spectrometers is now available with electron transfer dissociation (ETD) and matrix-assisted laser desorption/ionisation (Maldi) capabilities
Results of these studies have been shown in recent seminars, technical posters, and presentations at major scientific conferences.
"ETD will help shed new light on many important, unanswered questions in contemporary biology," said Dr Don Hunt, principal investigator at the University of Virginia.
"ETD represents a landmark advance in the field of proteomics".
"This new methodology is a powerful and reliable analytical solution for protein characterization." Dr Hunt has used ETD to characterize the biochemical basis of histone protein action in the regulation of DNA transcription.
Additionally, he has shown that the pattern of histone phosphorylation, methylation and acetylation is critical to DNA expression".
"These studies would not have been possible without ETD," added Hunt.
"Thermo has been working closely for several years with Dr Hunt's laboratory on the development of ETD, and we are pleased to be licensing it from the University of Virginia," said Iain Mylchreest, vice president and general manager, life sciences mass spectrometry at Thermo Electron.
"This clearly demonstrates Thermo's commitment to acquiring innovative new technologies and developing integrated solutions that address the research and analytical challenges facing the proteomics community.".
• Thermo Fisher Scientific (Mass Spectrometry): contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
