Product category:
Mass spectrometers
News Release from: Thermo Fisher Scientific (Mass Spectrometry)
Edited by the Laboratorytalk Editorial
Team on 31 January 2007
Cohesive Technologies acquisition boosts
LC-MS/MS
Thermo Fisher Scientific announces the acquisition of Cohesive Technologies, a manufacturer of advanced sample extraction and high performance liquid chromatography products
TurboFlow technology enhances the existing Thermo Scientific liquid chromatography (LC) and mass spectrometry (MS) product portfolio by minimising sample preparation in LC, especially for drug discovery, drug development and clinical research applications This unique solution allows scientists to reduce matrix effects during pre-clinical bioanalysis, making it easier to comply with the FDA/CDER bioanalytical method validation guidance that states that 'In the case of LC-MS-MS-based procedures, appropriate steps should be taken to ensure the lack of matrix effects throughout the application of the method, especially if the nature of the matrix changes from the matrix used during method validation'
This article was originally published on Laboratorytalk on 13 Nov 2003 at 8.00am (UK)
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High-performance MS to boost bio-analysis research
With a purchase price of euro 800,000 and funded by the German Research Council, this new equipment will make Giessen University one of the best-equipped bio-analysis facilities in Europe
The TurboFlow technology works by retaining small molecules, filtering out proteins and larger materials by diffusion, size exclusion and column chemistry.
This enables users to directly inject biological samples into the LC-MS/MS system prior to analysis, a significant advantage in pre-clinical bioanalysis, where extensive sample preparation is too time-consuming due to the high sample loads.
TurboFlow technology can be coupled with the Thermo Scientific TSQ Quantum triple quadrupole mass spectrometer combined with Faims (high-field asymmetric ion mobility mass spectrometry) to achieve a unique LC-MS/MS solution.
When configured to the TSQ Quantum, the system delivers fast and efficient quantitative results with the lowest ion suppression and chemical noise, resulting in highly sensitive bioanalytical methods, development of more robust methods, and reduction in analysis failures.
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