Product category:
Instrument control software
News Release from: Thermo Fisher Scientific (Mass Spectrometry) | Subject: QuickQuan
Edited by the Laboratorytalk Editorial
Team on 01 June 2007
LC-MS/MS software speeds compound
assessment
Thermo Fisher Scientific unveils additions to its LC-MS/MS software suite to reduce time to assess and evaluate thousands of new compounds for data review in drug discovery and development labs
The integration of Thermo Scientific QuickQuan software and Aria TLX system's multiplexing technology accelerates the pace of drug discovery, says the company For laboratories that perform high-throughput screening (HTS), the integrated solution allows scientists to quickly assess thousands of new chemical entity samples in drug discovery research
This article was originally published on Laboratorytalk on 20 Mar 2006 at 8.00am (UK)
Related stories
Software provides fast LC-MS/MS quantification
Thermo Electron has introduced QuickQuan software for automating high-throughput LC-MS/MS assays in early drug discovery.
Alleviating bottlenecks in sample analysis
Recently showcased at Pittcon 2007, Thermo Scientific QuickQuan 2.0 for automating high-throughput LC-MS/MS assays, designed to alleviate the bottleneck of sample analysis in early drug discovery
QuickQuan software performs automated optimisation of MS/MS parameters, enabling the rapid analysis of compounds.
Analytical parameters can now be sent to Aria software which controls the TLX system, combining automated optimisation with multiplexing to offer unmatched throughput for discovery applications such as: metabolic clearance, CACO2, Pampa, protein binding and in-vivo PK.
Data generated from QuickQuan can be seamlessly transferred to the Thermo Scientific Galileo Lims, enabling rapid data review and informed decision making.
Further reading
Integration of Aria LX technology with QuickQuan
The combination enables users to increase the throughput of compounds processed in high-throughput liquid chromatography-mass spectrometry (LC-MS) assays by a factor of four
New ion source for mass spectrometers
Ion source featuring rapidly interchangeable electrospray ionisation, nanospray, and atmospheric pressure chemical ionisation probes becomes standard
Using the QuickQuan optimisation parameters, Aria software controls the pumps to synchronise the introduction of samples to the TSQ Quantum triple quadruple mass spectrometer and maximise sample throughput.
One mass spectrometer with an Aria TLX-4 system can process as many samples as four standalone LC-MS/MS systems.
With the Aria multiplexed system, up to four parallel sample presentation channels are synchronised to a single mass spectrometer.
Specifically developed for HT-Adme studies that involve data processing of thousands of samples per week, Thermo Scientific QuickCalc Software powered by GMSU (Gubbs Mass Spec Utilities) reduces the time required to evaluate new compounds for drug development.
It enables researchers focusing on in vitro studies to process and review large quantities of data by automatically generating reports and storing the results in a relational database.
QuickCalc is a desktop application which typically serves smaller drug discovery labs, bridging the transition towards an enterprise-level data reduction system such as Galileo Lims.
QuickCalc software automates the assessment of data from HTS by integrating the chromatographic peaks, calculating pharmacokinetic parameters and generating summary reports.
Three modules enable researchers to accurately and efficiently process the sample data: the hepatic clearance calculator (for microsomes, hepatocytes, S9), the permeability calculator (for CACO-2, Pampa) and - exclusive to QuickCalc software - the PK Calculator for toxicokinetic parameters.
QuickCalc also eliminates the need to manually transfer text files to a second data system such as Microsoft Excel.
• Thermo Fisher Scientific (Mass Spectrometry): contact details and other news
• Email this article to a colleague
• Register for the free Laboratorytalk email newsletter
• Laboratorytalk Home Page
Search the Pro-Talk network of sites
