Product category:
Mass spectrometers
News Release from: Thermo Fisher Scientific (Mass Spectrometry) | Subject: Faims
Edited by the Laboratorytalk Editorial
Team on 06 December 2007
Faims validated for safety in drug
development
Thermo Fisher Scientific's Faims-based LC/MS analytical method is validated by A+M Labor fuer Analytik to ensure human safety in drug development; an animated video on CD is available on request
Researchers in Germany's A+M Labs have validated a method that uses innovative Thermo Scientific high-field asymmetric waveform ion mobility spectrometry (Faims) technology to remove interferences from a drug analysis Using this method, the researchers can adhere to the guidelines of the FDA to ensure human safety in drug development
This article was originally published on Laboratorytalk on 20 Jun 2006 at 8.00am (UK)
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Unforeseen analyte interferences can cause validated LC-MS methods to fail, resulting in costly delays in obtaining data from clinical trials.
Another impact of co-eluting interferences is data misinterpretation, which could cause dosing errors in human test subjects.
The method was presented to the scientific community at the annual LC/MS workshop in Wuppertal, Germany on 13 November 2007.
Axel Roemer, research leader at A+M, presented the findings.
"We were very impressed with how the Thermo Scientific Faims system allows us to remove interferences with our drug analysis method," said Roemer.
"Keeping at the forefront of science is important for us to bring new therapies to patients".
The Faims interface for the Thermo Scientific TSQ Quantum series of mass spectrometers works in combination with the H-ESI and APCI ion probes at atmospheric pressure to increase selectivity during analysis.
Faims provides additional ion filtering, resulting in LC-MS/MS chromatograms with reduced chemical background and endogenous interferences.
"We are pleased that Dr Roemer and his team at A+M Labs could develop a validated LC-MS assay using Faims technology with such significance to human health," said Jim Kapron, strategic marketing specialist at Thermo Fisher Scientific.
Thermo has created a CD featuring animated video about Faims, which can be ordered free of charge.
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