Product category:
Viscometers and rheometers
News Release from: Viscotek Europe | Subject: Triple detection GPC/SEC
Edited by the Laboratorytalk Editorial
Team on 29 February 2008
Rapid method for characterisation of
excipients
A new application report from Viscotek describes how its triple detection GPC/SEC system provides a rapid and convenient way of characterising chitosans
Chitosans are natural products derived from chitin, which is commonly found in the shells of crustaceans, and is a renewable resource nearly as abundant as cellulose Chitosans are a focus of interest for various applications
This article was originally published on Laboratorytalk on 24 May 2007 at 8.00am (UK)
Related stories
Booklet explains triple detection GPC/SEC
Technique combines a concentration detector (refractive index or UV-Visible), viscometer and light scattering detector acting in concert, with each providing complementary but different information
They can be used in a range of cosmetic and pharmaceutical applications as they are biocompatible, hypoallergenic, biodegradable and bioabsorbable.
To optimise their properties for a specific application chitosans are often chemically modified.
The wide use of chitosans as excipient materials has created a demand for effective methods for determining their molecular weight distribution and structure.
In the application report three chitosan samples are characterised using a Viscotek triple detection system (TDA) that allows rapid determination of molecular weight, size and conformational structure in a single experiment.
The Viscotek TDA employs a refractive index detector, viscometer and low angle light scattering (Lals) detector acting in concert, with each detector providing complimentary but different information.
The signal-to-noise on all three detectors is excellent, which ensures the quality of the calculated data.
The report shows that despite differences in molecular weight and polydispersity the structure of the three samples analysed were similar. Request a free brochure from Viscotek Europe ...
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