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News Release from: Waters | Subject: Mass spectrometers
Edited by the Laboratorytalk Editorial
Team on 13 September 2005
Practical applications in mass
spectrometry
Waters has announced its participation in poster sessions at the Second Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology and Pharmaceutical Industries
Sponsored by the California Separation Science Society (CaSSS), the symposium takes place 12-13 September 2005 at the Hilton Back Bay hotel in Boston, USA The symposium emphasises the application of MS for product characterisation, process monitoring, formulation development, and release testing for protein therapeutics, the fastest growing segment of the pharmaceutical market
This article was originally published on Laboratorytalk on 30 Jun 2005 at 8.00am (UK)
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These complex biological macromolecules require extensive analytical characterisation.
Mass spectrometry's high specificity and high throughput make it an ideal analytical tool to define protein structure and demonstrate manufacturing consistency.
Posters from Waters's deployment of MS in drug discovery, product development and quality control include the following:.
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Rapid measurement of protein modifications by combining exact mass measurement ms and advanced spectral deconvolution.
Purity analysis and identity confirmation of proteins using optimised reversed phase chromatography LC/exact mass Tof-MS systems.
Systematic strategies for developing peptide maps.
Detection and measurement of protein modification and damage in complex samples using exact mass measurement.
Identification of N-linked glycosylation sites using Maldi tandem time-of-flight mass spectrometry.
Increased resolution in peptide separations using UPLC.
Probing aging in Zucker rats using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry.
Development of orthogonal separation methods for 2D-HPLC (MS/MS) analysis of peptides.
Improved peptide identification and protein coverage for proteomic samples using novel alternative 2D-HPLC MS/MS approaches.
Obtaining high sequence coverage LC/MS peptide maps using an integrated MS/multiplexed MS/MS data acquisition strategy.
According to Jeff Mazzeo, director of applied technology at Waters: "More and more scientists at biopharmaceutical firms are moving to MS and LC/MS assays for ID testing, structural analysis, determination of modified forms and comparability studies.
"The symposium offers a forum for industry experts to explore the benefits this technology offers over conventional assays.
"We are pleased to participate and look forward to sharing our data and learning from other's research as well".
The California Separation Science Society (CaSSS) is a not-for-profit chromatography discussion group serving separation scientists in California.
The purpose of the society is to provide a professional forum for the dissemination of information and technology regarding separation science.
CaSSS sponsors numerous one-day symposia focused on particular areas of separation science.
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