Product category:
Other analytical instruments
News Release from: Waters | Subject: Maldi Synapt HDMS system
Edited by the Laboratorytalk Editorial
Team on 13 June 2007
Redefining molecular characterisation
science
Waters highlighted new mass spectrometry, proteomics and software innovations focused on characterising and visualising molecules at the 55th annual American Society for Mass Spectrometry, 3-7 June
Complete characterisation ensures that a biological or chemical compound identity, purity, potency and stability are well-documented in order to identify molecular variations, safety and efficacy features, effective production processes, and/or product consistency Highlighting new product introductions is the ASMS premiere of the Waters Maldi Synapt mass spectrometer and the IdentityE high definition proteomics system for complex analysis of biological molecules
This article was originally published on Laboratorytalk on 2 Aug 2004 at 8.00am (UK)
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The Waters Maldi Synapt HDMS system is the first commercially available MS system to incorporate matrix-assisted laser desorption ionisation (Maldi) together with ion-mobility and time-of-flight (Tof) technology to redefine how biologically-significant molecules from drug metabolites to intact proteins are characterised.
Further reading
Taking liquid chromatography a stage further
Claiming to be the first end-to-end ultra performance liquid chromatography system offering specially designed column chemistries, hardware, software, and documentation
Expanded chromatography control with this software
Acquires data and controls the operation of and processes data from Waters brand instrumentation as well as Agilent photodiode array detectors, liquid chromatographs, and gas chromatographs
Training catalogue in eight regional versions
Courses for LC and MS technologies cover five major areas: laboratory informatics, instrument operation and maintenance, MS technologies, compliance and general chromatography
The second HDMS system to be introduced by Waters in the last 12 months, the system is intended for researchers working at the limits of conventional MS who need to further characterise and define their samples.
The Waters Maldi Synapt HDMS system is a dual ionisation mass spectrometer featuring both Maldi and atmospheric pressure ionisation (API) capability as standard features giving scientists maximum analytical power for discovery research challenges.
The system is operable in both time-of-flight (Tof) mode for exact mass UPLC/MS/MS experiments, and ion-mobility/Tof mode for performing novel ion mobility separations-based investigations.
Interest in the Waters Synapt HDMS System has been building since its introduction, says the company.
On 23 May 2007 more than 600 scientists registered for a webinar on Synapt.
At this year's Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Waters won the prestigious 2007 Pittcon Editors' Gold Award for best new product with its Synapt high definition MS (HDMS) system.
It also won the first place award from Instrument Business Outlook for best new product at Pittcon.
Waters is also showcasing its new IdentityE System, a UPLC/MSE system for qualitative proteomics.
The IdentityE high definition proteomics system is an UltraPerformance LC (UPLC)/high-bandwidth mass spectrometry (MSE) system solution suitable for confident protein identification designed to meet stringent requirements as outlined by leading scientific journals.
The new Waters IdentityE high definition proteomics system catalogues complex protein digest mixtures containing tens of thousands of peptides.
The system features a Waters Nanoacquity UPLC system for high chromatographic peak capacity and retention time reproducibility, together with an electrospray tandem mass spectrometer - Waters Q-Tof Premier or Waters Synapt HDMS system - for high dynamic mass resolution and consistent over-sampling of complex protein digests - two hallmarks of high definition proteomics.
Waters comprehensive peptide ion accounting informatics mine deeper into UPLC/MSE data to identify more peptides/proteins with greater sequence coverage and statistical rigour than conventional LC/MS/MS methods.
This system is fully supported with quality control standards, defined methods, training and support to ensure reproducible operation and consistent results.
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