Product category:
Proteomics
News Release from: Waters | Subject: Synapt HDMS system
Edited by the Laboratorytalk Editorial
Team on 11 October 2007
High definition proteomics showcased at
Hupo 2007
At the Human Proteome Organisation's 6th annual world congress, Waters showed several technologies expected to give proteomics researchers new insights into the workings of the human proteome
The Waters Synapt HDMS system is intended for researchers working at the limits of conventional mass spectrometry (MS) and who need to further characterise and define their samples The Synapt HDMS system is the first mass spectrometer of its kind to employ high efficiency ion-mobility based measurements and separations and specialised software to enable the analysis of sample ions differentiated by size, shape and charge as well as mass
This article was originally published on Laboratorytalk on 7 Jun 2006 at 8.00am (UK)
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A technological first for mass spectrometry
Synapt HDMS is the first mass spectrometer of its kind to employ new ion-mobility technology and software to enable the analysis of sample ions differentiated by size and shape, as well as mass
This additional dimension of separations fidelity leads to improved specificity and sample definition, meaning scientists can extract more information about their samples including the detection of previously unseen constituents.
The United Kingdom's Oxford University, Cambridge University, University of Warwick, University of Leeds, and Nottingham University, in addition to Utrecht University, Netherlands, and the Max Planck Institute, Martinsreid, Germany use the Synapt HDMS for the study of proteins and to shed light on the causes of some of the world's most pernicious protein-misfolding diseases including Alzheimer's, Parkinson's, Huntington's and 'mad cow' diseases.
The Waters IdentityE high definition proteomics system for label-free protein identification is an ultraperformance LC (UPLC)/high-bandwidth mass spectrometry (MSE) system solution designed for highly-confident protein identification and to meet stringent requirements as outlined by leading scientific journals.
IdentityE catalogues complex protein digest mixtures containing tens of thousands of peptides.
The system features a Waters Nanoacquity ultraperformance LC(UPLC) system for high chromatographic peak capacity and retention time reproducibility, together with an electrospray tandem mass spectrometer - Waters Q-Tof Premier or Waters Synapt HDMS - for high dynamic mass resolution and consistent over-sampling of complex protein digests - two hallmarks of high definition proteomics.
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