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News Release from: Zinsser Analytic (UK) | Subject: Automatic workbench
Edited by the Laboratorytalk Editorial
Team on 15 July 2005
Take a closer look at drug discovery
workflows
Automatic workbench enables users to execute a workflow to test a large number of compounds in parallel, based on the microplate format for either 24, 48, or 96 compounds or testing parameters
The continuous rise in costs for pharmaceutical products forces us to take a closer look at traditional workflows, says Zinsser Analytic So far in the early stages of drug discovery, the focus was on the chemical effects, leaving the analysis of the physical effects using formulation and solubility studies as the last link in the process
This article was originally published on Laboratorytalk on 14 Jun 2002 at 8.00am (UK)
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This approach could lead to the terrible consequence of missing important required properties for dosage, solubility, storage etc.
All the money spent on the discovery so far would have been totally wasted.
To avoid more disappointment and financial disaster in the final development stage it is crucial to have already eliminated unsuitable compounds at an earlier stage.
New workflows and hardware systems are required which enable us to deal with the small volumes of material available at the early discovery stage in order to study the physical and chemical properties.
Zinsser Analytic has developed an automatic workbench which enables users to execute a workflow to test a large number of compounds in parallel.
The reactor is based on the microplate format for either 24, 48, or 96 different compounds or different testing parameters.
Tools for pH measurement and adjustment, precision dosage, weighing and mixing (even of highly viscous media) are provided.
Optical control, evaporation, filtration, HPLC/LC-MS integration can be provided enabling users to carry out proven formulation methods and solubility tests on a single platform.
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