System simulates in vivo breathing profiles
BRS 3000 delivers the flow rates required to test metered dose inhalers (MDIs) and dry powder inhalers (DPIs).
Designed to allow closer simulation of in vivo breathing profiles, the BRS 3000 generates flow rates up to 240 litres per minute with a maximum 25 litres per second2 acceleration rate; volume capacity is 5 litres.
Companion to the smaller BRS 2000 unit, which is designed principally for nebulisers, the BRS 3000 allows users to define and apply breathing profiles that mimic those of the patient during inhaler use.
This enables the exploration of DPI and MDI performance under test conditions that more accurately reflect use by specific patient groups, including different age categories or those with acutely impaired lung function.
Both the BRS 2000 and BRS 3000 breath simulators can be configured for in vitro dose uniformity and aerodynamic particle size distribution data measurement (by cascade impaction), to apply user-defined patient profiles, rather than the fixed flow rates associated with routine testing.
Each breath simulator allows the application of various different waveforms including user-defined flow rate versus time profiles.
Standard sinusoidal, rectangular and triangular waveforms can also be generated with control over inhalation/exhalation ratio, breath volume, breathing duration and breaths per minute.
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