Using the Actipix dissolution imager from Paraytec formulation scientists are able 'to see' in real time what is happening at a tablet surface during the process of dissolution.
Due to be launched at Pittcon 2009 on 9 March 2009, the product offers pharmaceutical companies a tool that can reduce the time it takes a drug to come to market, thereby offering potential gains in earnings.
The development of most modern drug therapies requires advanced drug formulations.
It is important therefore to understand the mechanism of drug release behaviour, as this regulates the performance of many solid pharmaceutical dosage formulations.
To date, only high cost, complex-to-use techniques such as terahertz spectroscopic imaging and magnetic resonance imaging (MRI) have been able to solicit the data to enable formulation scientists to understand complex pharmaceutical drug release processes.
The Actipix dissolution imager overcomes these limitations and provides an affordable dissolution-imaging capability for scientists, which does not require expert operation.
Using a specially designed tablet holder - controlled release pharmaceuticals can be studied using Paraytec's Actipix D-100 UV area imager.
The holder is placed inside the Actipix D-100, which enables real-time recording and review of data.
When liquid flows over the surface of the formulation, release of the active ingredient can be quantitatively monitored directly at the tablet surface.
The Actipix D100 is a quantitative UV area imaging system.
The miniature detector contains a high-resolution 1280 x 1024 active pixel sensor.
Compact in design, the Actipix D100 consists of a control box connected via a fibre optic cable and communications cable to a remote sensor head.
The sensor head holds easily exchangeable, application-specific cartridges.
The cartridges are used in conjunction with software, enabling the end user to easily switch between applications.
The detector can be used as a 'plug-and-play' accessory linked in-line to single or multiple peripheral devices, such as syringe pumps, existing CE or nanoLC instrumentation.
These can be further coupled to other devices such as mass spectrometers giving a greater depth of information.
Detection is performed at a selected wavelength by means of interchangeable filters.
The detector wavelength range is 190 to 1100nm.
