Bio-Synthesis, a custom biomedical manufacturer, has launched the Peptide Library Generation Tools software, complete with six screening tools.
These tools are each designed to help with epitope identification and sequence optimisation to best fit the customer's current/future applications.
They include the Overlapping Peptide Library, the Alanine Scanning Library, the Positional Library, the Truncation Library, the Random Library and the Scrambled Library.
Each library has a different ability to assist and evaluate sequences based on the researcher's specific needs.
The Overlapping Peptide Library breaks down the original protein or peptide into fragments of equal length, allowing the researcher to see which segments of the original protein or peptide yield the highest activity.
The Alanine Scanning Library is useful in identifying which amino acids are essential to the peptide's function by indicating the level of importance associated with each replaced amino acid.
The Positional Library is used when a position or positions in a peptide sequence are each replaced with different amino acids in order to determine the preferred amino acid residues at these positions.
The Truncation Library is said to be useful for determining the minimum length required for optimum peptide activity.
The goal of the Random Library protocol is to substitute randomly selected amino acids with a mixture of all 20 amino acids.
The Scrambled Library is used to examine all possible combinations of the same amino acids from the original sequence.
The sequences generated through the Peptide Library Generation Tools software can then be passed to Bio-Synthesis for custom synthesis.
