Microplate reader technology at ELRIG 2012

The company will be exhibiting at booth Q11 & Q12. It will be offering visitors a chance learn how its technology enhances microplate applications.

When designing its newest microplate readers, BMG LABTECH analysed the market to determine what features are missing in a microplate reader that will enhance life science applications.

Two such advancements that greatly improve assays are ultra-fast, full spectrum analysis for absorbance assays and Direct Optic Bottom Reading for cell-based assays.

At ELRIG 2012, BMG LABTECH will present how to use the SoPRano label-free technology in a simple spectrometer-based absorbance reader to obtain protein-protein binding kinetics such as the association (k_a) and dissociation (k_d) rates, as well as EC/IC₅₀ and K_D values.

With the SoPRano assay and BMG LABTECH’s ultra-fast, full spectrum analysis with a CCD-spectrometer, label-free applications are possible without purchasing expensive, dedicated SPR equipment.

In addition, BMG LABTECH will show how cell-based assays greatly benefit from its innovative Direct Optic Bottom Reading design.

When automating cell-based assays to an HTS or HCS platform, loss of sensitivity is a concern.

The group will show how Direct Optic Bottom Reading on the PHERAstar FS achieves signal-to-blank ratios in fluorescent cell-based assays like GFP, mCherry, and mOrange that are more than 300% higher than other microplate readers.

With this level of sensitivity, obtaining higher throughput from an existing FACS or a confocal microscope assay is possible.