New findings in drug-induced receptor activity are highlighted with the help of Roche's xCELLigence System
A research team led by Dr Michel Bouvier at the Institute for Research in Immunology and Cancer (IRIC) used the Roche xCELLigence SP Instrument to measure changes in cell response following ligand stimulation.
According to their findings, selective pharmacological inhibition of specific arms of the B2AR signaling network was able to correlate the differential contribution of signaling events to specific components of the cell response.
The essential role of intracellular Ca2+ in the cell response also led to the discovery of a novel B2AR-promoted Ca2+ mobilization event.
The discovery that drugs targeting a single G protein-coupled receptor (GPCR) can differentially modulate distinct subsets of the receptor signaling repertoire is a very important step in drug discovery, said Roche.
